La genética contemporánea entre moléculas y cuerpos: un ensayo historiográfico
DOI:
https://doi.org/10.3989/asclepio.2025.1432Palabras clave:
Herencia biológica, Biología molecular, Discriminación, Cromosomas, genetizaciónResumen
Esta revisión historiográfica ofrece una reflexión que sitúa los sucesivos momentos político-epistémicos en los que se han construido los trabajos, los estudios y el pensamiento sobre historia de la genética. Se defiende que la historia de la genética molecular (o biología molecular), como la genetización de la biología, surge con los resultados cautivadores y prometedores de los primeros experimentos de ingeniería genética a mediados de la década de 1970 y se expande hasta los estudios críticos de la genómica. Se revisa aquí el esfuerzo historiográfico por comprender la biologización de las diferencias y los prejuicios, que ha buscado en moléculas y cromosomas justificaciones de las prácticas culturales y sociales del racismo, el clasismo y contra la diversidad de género y las capacidades intelectuales y físicas. La deuda con las pensadoras críticas de la biología y de sus sesgos de género y étnico-racionales es enorme.
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Abir-Am, Pnina. 1982a. "The Discourse of Physical Power and Biological Knowledge in the 1930s: A Reappraisal of the Rockefeller Foundation's Policy in Molecular Biology". Social Studies of Science 12 (3): 341-382. https://doi.org/10.1177/030631282012003001 PMid:11611075
Abir-Am, Pnina G. 1982b. "How scientists view their heroes: Some remarks on the mechanism of myth construction". Journal of the History of Biology 15 (2): 281-315. https://doi.org/10.1007/BF00233019 PMid:11611044
Abir-Am, Pnina G. 1989. "The biotheoretical gathering, trans-disciplinary authority and the incipient legitimation of molecular biology".
Abir‐Am, Pnina. 1992a. "A historical ethnography of a scientific anniversary in molecular biology: The first protein X‐ray photograph (1984, 1934)". Social Epistemology 6 (4): 323-354. https://doi.org/10.1080/02691729208578670
Abir-Am, Pnina G. 1992b. "The politics of macromolecules: Molecular biologists, biochemists, and rhetoric". Osiris 7: 164-191. https://doi.org/10.1086/368709 PMid:11615242
Amsterdamska, Olga. 1993. "From pneumonia to DNA: The research career of Oswald T. Avery". Historical Studies in the Physical and Biological Sciences 24 (1): 1-40. https://doi.org/10.2307/27757711 PMid:11623400
Andreu-Miralles, Xavier y Mónica Bolufer-Peruga. 2022. European Modernity and the Passionate South: Gender and Nation in Spain and Italy in the Long Nineteenth Century. Brill. https://doi.org/10.1163/9789004527225
Bangham, Jenny. 2020. Blood relations: Transfusion and the making of human genetics. Chicago: University of Chicago Press. https://doi.org/10.7208/chicago/9780226740171.001.0001
Barahona, Ana. 2016. "Medical genetics and the first studies of the genetics of populations in Mexico". Genetics 204 (1): 11-19. https://doi.org/10.1534/genetics.116.191767 PMid:27601615 PMCid:PMC5012378
Bateson, Beatrice. 2009 [1928]. William Bateson, Naturalist: His Essays and Addresses Together with a Short Account of His Life. Cambridge: Cambridge University Press. https://doi.org/10.1017/CBO9780511693946
Bolufer, Mónica. 2016. "Orientalizing Southern Europe?: Spain Through the Eyes of Foreign Travelers". The Eighteenth Century 57 (4): 451-467. https://doi.org/10.1353/ecy.2016.0031
Bowker, Geoffrey y Susan Leigh Star. 2000. Sorting things out. Classification and its consequences. Cambridge, Massachusetts: The MIT Press. https://doi.org/10.7551/mitpress/6352.001.0001
Brauckmann, Sabine, Christina Brandt, Denis Thieffry y Gerd B. Müller, eds. 2009. Graphing Genes, Cells, and Embryos. Cultures of Seeing 3D and Beyond. Preprint. Berlin: Max-Planck Institut für Wissenschaftsgeschichte.
Brooks, Harvey. 1978. "The problem of research priorities", Dedalus 107: 171-190.
Bud, Robert. 2010. "From applied microbiology to biotechnology: Science, medicine and industrial renewal". Notes and Records of the Royal Society 64 (suppl 1): S17-S29. https://doi.org/10.1098/rsnr.2010.0044 PMid:20973345
Buklijas, Tatjana y Nick Hopwood. 2008-2010. Making visible embryos, An online exhibition developed by the University of Cambridge with support from the Wellcome Trust, http://www.sites.hps.cam.ac.uk/visibleembryos/.
Burton, Elise K. 2022. "Ashkenazi Anxieties: A Transnational Social History of Jewish Genetic Admixture Modeling, 1971-1986". Journal of the History of Biology 55 (3): 411-442. https://doi.org/10.1007/s10739-022-09693-6 PMid:36322260
Campos, Luis A. 2015. Radium and the Secret of Life. Chicago: University of Chicago Press. https://doi.org/10.7208/chicago/9780226238302.001.0001
Campos, Luis y Francesco Cassata. 2025. "Introduction: Revis(it)ing Asilomar." Journal of the History of Biology 58 (1): 1-12. https://doi.org/10.1007/s10739-025-09817-8 PMid:40261599
Cassata, Francesco y Soraya de Chadarevian. 2025. "Asilomar Across the Atlantic: EMBO, EMBL, and the Politics of Scientific Expertise". Journal of the History of Biology 58 (1): 95-132. https://doi.org/10.1007/s10739-025-09808-9 PMid:40038174 PMCid:PMC12098474
Creager, Angela N. H. 1996. "Wendell Stanley's dream of a free-standing biochemistry department at the University of California, Berkeley". Journal of the History of Biology 29: 331-360. https://doi.org/10.1007/BF00127379 PMid:11618361
Creager, Angela N. H. 2002. The life of a virus: Tobacco mosaic virus as an experimental model, 1930-1965. Chicago: University of Chicago Press.
Creager, Angela N. H. 2006. "Nuclear energy in the service of biomedicine: The US Atomic Energy Commission's radioisotope program, 1946-1950". Journal of the History of Biology 39: 649-684. https://doi.org/10.1007/s10739-006-9108-2 PMid:17575955
Creager, Angela N. H. 2013. Life atomic: A history of radioisotopes in science and medicine. Chicago: University of Chicago Press. https://doi.org/10.7208/chicago/9780226017945.001.0001
Creager, Angela N. H. y Jean-Paul Gaudillière. 1996. "Meanings in Search of Experiments and Vice-versa: the Invention of Allosteric regulation in Paris and Berkeley, 1959-1968". Historical Studies in the Physical and Biological Sciences 27 (1): 1-89. https://doi.org/10.2307/27757769
Creager, Angela N. H. y María Jesús Santesmases. 2006. "Radiobiology in the atomic age: Changing research practices and policies in comparative perspective". Introduction to a special issue of Journal of the History of Biology 39: 637-647. https://doi.org/10.1007/s10739-006-9107-3
Cueto, Marcos, ed. 1994. Missionaries of Science: The Rockefeller Foundation and Latin America. Bloomington: Indiana University Press. https://doi.org/10.2979/2358.0
Curry, Helen Anne. 2016. Evolution made to order, Plant breeding and technological innovation in twentieth-century America. Chicago: University of Chicago Press. https://doi.org/10.7208/chicago/9780226390116.001.0001
Curry, Helen Anne. 2022. Endangered maize, Industrial agriculture and the crisis of extinction. Berkeley: University of California Press. https://doi.org/10.1525/9780520973794
Darwin, Charles. 2008 [1868]. La variación de los animales y las plantas en domesticación. Vols. 1 y 2. Editorial CSIC-CSIC Press.
Darnton, Robert. 1982. "What is the History of Books?". Daedalus 111: 65-83.
Darnton, Robert. 2007. "What is the history of books?" revisited". Modern Intellectual History 4: 495-508. https://doi.org/10.1017/S1479244307001370
Daston, Lorraine y Peter Galison. 2007. Objectivity. New York: Zone Books.
De Chadarevian, Soraya. 2002. Designs for life: Molecular biology after World War II. Cambridge: Cambridge University Press.
De Chadarevian, Soraya. 2003. "Portrait of a discovery: Watson, Crick, and the double helix". Isis 94 (1): 90-105. https://doi.org/10.1086/376100 PMid:12725105
De Chadarevian, Soraya. 2020. Heredity under the Microscope: Chromosomes and the Study of the Human Genome. Chicago: University of Chicago Press. https://doi.org/10.7208/chicago/9780226685250.001.0001
De Chadarevian, Soraya y Harmke Kamminga, eds. 1998. Molecularizing biology and medicine: new practices and alliances, 1920s to 1970s. Amsterdam: Harwood.
De Chadarevian, Soraya y Jean-Paul Gaudillière, eds. 1996. "The tools of the discipline: biochemists and molecular biologists". Monográfico del Journal of the History of Biology 29 (3). https://doi.org/10.1007/BF00127378
Del Cura González, Mercedes. 2011. Medicina y pedagogía. La construcción de la categoría «infancia anormal» en España (1900-1939). Madrid: Consejo Superior de Investigaciones Científicas.
Delgado Echeverría, Isabel. 2007. El descubrimiento de los cromosomas sexuales: un hito en la historia de la biología. Madrid: CSIC.
Derrida, Jacques. 1992 [1967]. De la grammatologie. Hans-Jörg Rheinberger and Hans Zischler, tradución del francés al alemán. Frankfurt: Suhrkamp.
Eder, Sandra. 2022. How the clinic made gender: the medical history of a transformative idea. Chicago: University of Chicago Press. https://doi.org/10.7208/chicago/9780226573465.001.0001
Fausto-Sterling, Anne. 2006 [2000]. Cuerpos sexuados. La política de género y la construcción de la sexualidad. Traducido por Ambrosio García Leal. Barcelona: Melusina.
García-Sancho, Miguel. 2010. "A new insight into Sanger's development of sequencing: From proteins to DNA, 1943-1977". Journal of the History of Biology 43: 265-323. https://doi.org/10.1007/s10739-009-9184-1
García-Sancho, Miguel. 2012. Biology, computing, and the history of molecular sequencing: from proteins to DNA, 1945-2000. Londres: Palgrave Mcmillan.
García-Sancho, Miguel, Rhodri Leng, Gil Viry, Mark Wong, Niki Vermeulen, y James Lowe. 2022. The Human Genome Project as a singular episode in the history of genomics. Historical Studies in the Natural Sciences 52 (3): 320-360. https://doi.org/10.1525/hsns.2022.52.3.320
García-Sancho, Miguel, Matiana González-Silva y María Jesús Santesmases. 2014. "Shaping biomedical objects across history and philosophy: a conversation with Hans-Jörg Rheinberger". Dynamis 34 (1): 193-209.
Gaudillière, Jean-Paul. 1996. "Molecular biologists, biochemists, and messenger RNA: the birth of a scientific network". Journal of the History of Biology 29: 417-445. https://doi.org/10.1007/BF00127382 PMid:11618364
Gaudillière, Jean-Paul. 2002. Inventer la biomédicine. La France, l'Amérique et la production des savoirs du vivant (1945-1965). París: La Découvert. https://doi.org/10.3917/dec.gaudi.2002.01 PMid:12235147
Gaudillière, Jean-Paul y Hans-Jörg Rheinberger, eds. 2004. From molecular genetics to genomics. New York: Routledge. https://doi.org/10.4324/9780203375334
Gausemeier, Bernd, Staffan Müller-Wille y Edmund Ramsden, eds. 2014. Human Heredity in the Twentieth Century. Londres: Pickering & Chatto.
Gautier, Marthe. 2009. «Cinquantenaire de la trisomie 21-Retour sur une découverte». médecine/sciences 25: 311-16. https://doi.org/10.1051/medsci/2009253311 PMid:19361398
Geison, Gerald L. 1995. The Private Science of Louis Pasteur. Princeton: Princeton University Press. https://doi.org/10.1515/9781400864089
Gill-Peterson, Jules. 2022. Historias de la infancia trans. Barcelona: Bellaterra.
Ha, Nathan Q. 2011. "The riddle of sex: Biological theories of sexual difference in the early twentieth-century". Journal of the History of Biology 44: 505-546. https://doi.org/10.1007/s10739-010-9257-1 PMid:21082219
Ha, Nathan Q. 2014. "Diagnosing sex chromatin: a binary for every cell". Historical Studies in the Natural Sciences 45 (1): 49-84. https://doi.org/10.1525/hsns.2015.45.1.49
Hamblin, Jacob Darwin. 2007. "'A Dispassionate and Objective Effort': Negotiating the First Study on the Biological Effects of Atomic Radiation". Journal of the History of Biology 40: 147-177. https://doi.org/10.1007/s10739-005-6531-8 PMid:17993170
Núñez Casal, Andrea. 2024. "Race and indigeneity in human microbiome science: microbiomisation and the historiality of otherness". History and Philosophy of the Life Sciences 46 (2): 17. https://doi.org/10.1007/s40656-024-00614-w PMid:38565750 PMCid:PMC10987353
Olby, Robert Cecil. 1966. Origins of Mendelism. London: Constable.
Olby, Robert Cecil. 1991 [1974]. El camino hacia la doble hélice. Traducido por Natividad Sanchez Sainz-Trapaga. Madrid: Alianza Editorial.
Petermann, Heike I., Peter S. Harper y Susanne Doetz. 2017. History of Human Genetics. Aspects of Its Development and Global Perspectives. Cham: Springer. https://doi.org/10.1007/978-3-319-51783-4
Rader, Karen. 2004. Making mice: Standardizing animals for American biomedical research, 1900-1955. Princeton: Princeton University Press. https://doi.org/10.1515/9780691187587
Rasmussen, Nicolas. 1999. Picture control: The electron microscope and the transformation of biology in America, 1940-1960. Redwood City, CA: Stanford University Press.
Rheinberger, Hans-Jorg. 1997. Toward a history of epistemic things: Synthesizing proteins in the test tube. Redwood City, CA: Stanford University Press.
Rheinberger, Hans-Jörg. 2003 [2001]. "Los isótopos en funcionamiento: el contador de centello 1950-1970". En La física y las ciencias de la vida en el siglo XX: radiactividad y biología, editado por María Jesús Santesmases y Ana Romero de Pablos, 53-83. Madrid: Universidad Autónoma de Madrid-CSN.
Rheinberger, Hans-Jörg y Jean-Paul Gaudillière, eds. 2004. Classical Genetic Research and its Legacy. The Mapping Cultures of Twentiethcentury Genetics. London-New York: Routledge.
Rheinberger, Hans-Jörg y Staffan Müller-Wille. 2020. The gene: From genetics to postgenomics. University of Chicago Press.
Richardson, Sarah S. 2013. Sex itself, the search for male and female in the human genome. Chicago: University of Chicago Press. https://doi.org/10.7208/chicago/9780226084718.001.0001
Richmond, Marsha L. 1997. "'A Lab of One's Own'. The Balfour Biological Laboratory for Women at Cambridge University, 1884-1914". Isis 88: 422-455. https://doi.org/10.1086/383769 PMid:9450359
Richmond, Marsha L. 2006. "The 'domestication' of heredity, the familial organization of geneticists at Cambridge University, 1895-1910". Journal of the History of Biology 39 (3): 565-605. https://doi.org/10.1007/s10739-004-5431-7
Richmond, Marsha L. 2017. "Women as Public Scientists in the Atomic Age: Rachel Carson, Charlotte Auerbach, and Genetics". Historical Studies in the Natural Sciences 47 (3): 349-388. https://doi.org/10.1525/hsns.2017.47.3.349
Rodríguez Ocaña, Esteban. 2000. "La intervención de la Fundación Rockefeller en la creación de la sanidad contemporánea en España". Revista Española de Salud Pública 74: 27-34. https://doi.org/10.1590/S1135-57272000000600003
Rosón Villena, María. 2025. Entrevista. Sabor a queer 4x03. https://open.spotify.com/episode/5v9wdjrq87GeJkGEIGhtzG
.
Rosón Villena, María. 2021. "La memoria de las cosas: cultura material y vida cotidiana durante el franquismo". Kamchatka. Revista de análisis cultural 18: 5-14. https://doi.org/10.7203/KAM.18.21854
Santesmases, María Jesús. 2000. "Severo Ochoa and the biomedical sciences in Spain under Franco, 1959-1975". Isis 91 (4): 706-734. https://doi.org/10.1086/384946 PMid:11284230
Santesmases María Jesús. 2005. Severo Ochoa. De músculos a proteínas. Madrid: Síntesis.
Santesmases, María Jesús. 2006. "Peace propaganda and biomedical experimentation: Influential uses of radioisotopes in endocrinology and molecular genetics in Spain (1947-1971)". Journal of the History of Biology 39 (4): 765-794. https://doi.org/10.1007/s10739-006-9112-6 PMid:17575958
Santesmases, María Jesús. 2014. "Human chromosomes and cancer: Tumors and the geographies of cytogenetic practices, 1951-1956". Historical Studies in the Natural Sciences 45 (1): 85-114. https://doi.org/10.1525/hsns.2015.45.1.85
Santesmases, María Jesús. 2017. "Circulating biomedical images, Bodies and chromosomes in the post-eugenic era". History of Science 55 (4): 395-430. https://doi.org/10.1177/0073275317701145 PMid:28497705
Santesmases, María Jesús. 2020a. "Women in early human cytogenetics, An essay on a gendered history of chromosome imaging". Perspectives on Science 28 (2): 170-200. https://doi.org/10.1162/posc_a_00337
Santesmases, María Jesús. 2020b. "Standard making in cytogenetics: the manufacture, circulation and reproduction of chromosome images". Journal of History of Science and Technology 14 (1): 27-54. https://doi.org/10.2478/host-2020-0004
Santesmases, María Jesús y Antonio Calvo Roy. 2019. Rosalind Franklin. Madrid: Prisa.
Santesmases, María Jesús y Edna Suárez-Díaz. 2014. "A cell-based epistemology: Human genetics in the era of biomedicine". Introducción al monográfico Historical Studies in the Natural Sciences 45 (1): 1-13. https://doi.org/10.1525/hsns.2015.45.1.1
Santesmases, María Jesús y Miguel Ángel Rego Robles. 2025. "Formas y experiencias de entreguerras: artistas, genetistas y culturas visuales del norte de Europa y de América". En La especie inesperada. La condición humana desde el arte y la genética, coordinado por Francisco Antequera Márquez, José Gómez-Isla y Luis Castelo Sardina, 159-190. Madrid: CSIC.
Satzinger, Helga. 2008. "Theodor and Marcella Boveri: chromosomes and cytoplasm in heredity and development". Nature Reviews Genetics 9 (3): 231-238. https://doi.org/10.1038/nrg2311 PMid:18268510
Satzinger, Helga. 2012. "The politics of gender concepts in genetics and hormone research in Germany, 1900-1940". Gender & History 24 (3): 735-754. https://doi.org/10.1111/j.1468-0424.2012.01703.x
Sayre, Anne. 1997 [1975]. Rosalind Franklin y el ADN. Traducido por Teresa Carretero. Madrid: horas y Horas.
Schumpeter, Joseph A. 2002 [1939]. Ciclos económicos. Análisis teórico, histórico y estadístico del proceso capitalista. Traducido por Jordi Pascual. Zaragoza: Universidad de Zaragoza.
Smith, Jane S. 1990. Patenting the Sun: Polio and the Salk Vaccine. New York: Morrow.
Spanier, Bonnie. 1995. Im/partial science: Gender ideology in molecular biology. Bloomington: Indiana University Press. https://doi.org/10.2979/1989.0
Stern, Alexandra Minna. 2012. Telling genes: the story of genetic counseling in America. Baltimore: Johns Hopkins University Press.
Strasser, Bruno J. y Soraya de Chadarevian. 2011. "The comparative and the exemplary: revisiting the early history of molecular biology". History of Science 49 (3): 317-336. https://doi.org/10.1177/007327531104900305
Suárez-Díaz, Edna. 2014. "Indigenous populations in Mexico: Medical anthropology in the work of Ruben Lisker in the 1960s". Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 47: 108-117. https://doi.org/10.1016/j.shpsc.2014.05.011 PMid:25022488
Suárez-Díaz, Edna. 2017. "Blood Diseases in the Backyard: Mexican 'indígenas' as a Population of Cognition in the Mid-1960s". Perspectives on Science 25 (5): 606-630. https://doi.org/10.1162/POSC_a_00253
Suárez-Díaz, Edna y Ana Barahona. 2015. "Post-war and post-revolution: Medical genetics and social anthropology in Mexico, 1945-70". En Human heredity in the twentieth century, 101-112. Abingdon: Routledge.
Velasco Morgado, Raúl. 2016. Embriología en la periferia: las ciencias del desarrollo en la España de la II República y el franquismo. Madrid: CSIC.
Wade, Peter, Carlos López Beltrán, Eduardo Restrepo y Ricardo Ventura Santos, eds. 2014. Mestizo genomics: race mixture, nation, and science in Latin America. Durham, NC: Duke University Press. https://doi.org/10.1515/9780822376729
Watson, James. 1970 [1968]. La doble hélice. Traducido por Adolfo Martín. Barcelona: Plaza y Janés.
Werner, Petra. 1997. "Learning from an adversary? Warburg against Wieland". Historical Studies in the Physical and Biological Sciences 28 (1): 173-196. https://doi.org/10.2307/27757790 PMid:11620021
Wright, Susan. 1993. "The social warp of science: writing the history of genetic engineering policy". Science, Technology, & Human Values 18 (1): 79-101. https://doi.org/10.1177/016224399301800105 PMid:11652076
Wright, Susan. 1994. Molecular politics: Developing American and British regulatory policy for genetic engineering, 1972-1982. Chicago: University of Chicago Press.
Yi, Doogab. 2011. "Who owns what? Private ownership and the public interest in recombinant DNA technology in the 1970s". Isis 102 (3): 446-474. https://doi.org/10.1086/661619 PMid:22073770
Yi, Doogab. 2015. The recombinant university: Genetic engineering and the emergence of Stanford biotechnology. Chicago: University of Chicago Press. https://doi.org/10.7208/chicago/9780226216119.001.0001
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